Resources and Articles
Below you will find some of the most respected, peer-reviewed resources for pharmacogenomics information available
Resources
Clinical Pharmacogenetics Implementation Consortium Guidelines
Published with the assumption that pre-emptive (pre-prescription) genotyping will become more widespread, and that clinicians will be faced with having patients’ genotypes available even if they have not explicitly ordered a test with a specific drug in mind. As a result CPIC guidelines are designed to help clinicians understand HOW available genetic test results should be used to optimize drug therapy, rather than WHETHER tests should be ordered.
https://cpicpgx.org/guidelines/
DrugBank
It is a comprehensive, free-to-access, online database containing information on drugs and drug targets. It functions as both a bioinformatics and a cheminformatics resource, combining detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.
Drug Gene Interaction Database
A resource which collects and curates other resources and provides a simple interface for searching lists of genes against the existing compendia of known or potential drug-gene interactions.
FDA Table of Pharmacogenetic Associations
This resource lists pharmacogenetic associations that FDA has evaluated and believes there is sufficient scientific evidence to suggest that some patients with certain genetic variants are likely to have altered drug metabolism, and in certain cases, differential therapeutic effects, including differences in risks of adverse events.
https://www.fda.gov/medical-devices/precision-medicine/table-pharmacogenetic-associations
Flockhart Table
The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. It lists substrates, inhibitors and inducers of CYP450 enzymes.
GTMRx Institute
Their goal is to ensure appropriate and personalized use of medication and gene therapies by advancing to a scientific, evidence-based and cost-effective decision-making process and a team-based, systematic approach to medication use.
Implementing GeNomics In pracTiCe
An NIH-funded network dedicated to supporting the implementation of genomics in healthcare. The Network is comprised of five research sites, a coordinating center, a steering committee, and working groups.
MedlinePlus – Genetics Home Reference
Find consumer-friendly information about the effects of genetic variation on human health.
https://medlineplus.gov/genetics/
Pharmacogenomics Research Network
Lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects.
PharmGKB
A pharmacogenomics knowledge resource that encompasses clinical information including clinical guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships.
PharmVar
The Pharmacogene Variation (PharmVar) Consortium is a central repository for pharmacogene (PGx) variation that focuses on haplotype structure and allelic variation. The information in this resource facilitates basic and clinical research as well as the interpretation of pharmacogenetic test results to guide precision medicine.
Transformer
An open access database providing comprehensive information on the transformation and transport of xenobiotics in the human body.
http://bioinformatics.charite.de/transformer/